Induction of Aberrant Crypt Foci and Flat‐type Adenocarcinoma in the Colons of Dogs by N‐Ethyl‐N'‐nitro‐N‐nitrosoguanidine and Their Sequential Changes

Sequential endoscopic observation of dog colons was performed during colon carcinogenesis. Two beagle dogs were given suppositories containing N‐ethyl‐N'‐nitro‐N‐nitrosoguanidine (ENNG) every day for five months. In month 3, aberrant crypt foci (ACF), a putative preneoplastic lesion, were found...

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Veröffentlicht in:Jpn J Cancer Res
Hauptverfasser: Sugiyama, Kenji, Oda, Yasushi, Otori, Kazuhiko, Kato, Shigeharu, Hasebe, Takahiro, Fujii, Takahiro, Tajiri, Hisao, Esumi, Hiroyasu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 1997
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921272/
https://ncbi.nlm.nih.gov/pubmed/9414653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1997.tb00311.x
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