Induction of Aberrant Crypt Foci and Flat‐type Adenocarcinoma in the Colons of Dogs by N‐Ethyl‐N'‐nitro‐N‐nitrosoguanidine and Their Sequential Changes

Sequential endoscopic observation of dog colons was performed during colon carcinogenesis. Two beagle dogs were given suppositories containing N‐ethyl‐N'‐nitro‐N‐nitrosoguanidine (ENNG) every day for five months. In month 3, aberrant crypt foci (ACF), a putative preneoplastic lesion, were found...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Sugiyama, Kenji, Oda, Yasushi, Otori, Kazuhiko, Kato, Shigeharu, Hasebe, Takahiro, Fujii, Takahiro, Tajiri, Hisao, Esumi, Hiroyasu
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 1997
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921272/
https://ncbi.nlm.nih.gov/pubmed/9414653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1997.tb00311.x
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