LXR ligands induce apoptosis of EGFR-TKI-resistant human lung cancer cells in vitro by inhibiting Akt-NF-κB activation

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are efficient in treating patients with non-small cell lung cancer (NSCLC) harboring EGFR activating mutations. Unfortunately, nearly all patients ultimately acquire resistance to EGFR-TKI treatment. Liver X receptors (LXRs) can...

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Vydáno v:Oncol Lett
Hlavní autoři: Liu, Siwen, Cao, Haixia, Chen, Dan, Yu, Shaorong, Sha, Huanhuan, Wu, Jianzhong, Ma, Rong, Wang, Zhuo, Jing, Changwen, Zhang, Junying, Feng, Jifeng
Médium: Artigo
Jazyk:Inglês
Vydáno: D.A. Spandidos 2018
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921072/
https://ncbi.nlm.nih.gov/pubmed/29731879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2018.8182
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