Relationship between the Pharmacokinetics of Irinotecan and Diarrhea during Combination Chemotherapy with Cisplatin

Two phase I trials of irinotecan (CPT‐11) in combination with cisplatin were conducted. In both cases, the dose‐limiting toxicities were leukopenia and/or diarrhea. During these trials the pharmacokinetics of CPT‐11 and its active metabolite, 7‐ethyl‐10‐hydroxycamptothecin (SN‐38), were investigated...

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Udgivet i:Jpn J Cancer Res
Main Authors: Kudoh, Shinzoh, Fukuoka, Masahiro, Masuda, Noriyuki, Yoshikawa, Atsuko, Kusunoki, Yoko, Matsui, Kaoru, Negoro, Shun‐ichi, Takifuji, Nobuhide, Nakagawa, Kazuhiko, Hirashima, Tomonori, Yana, Takashi, Takada, Minoru
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 1995
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5920836/
https://ncbi.nlm.nih.gov/pubmed/7775263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1995.tb03071.x
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