Relationship between the Pharmacokinetics of Irinotecan and Diarrhea during Combination Chemotherapy with Cisplatin

Two phase I trials of irinotecan (CPT‐11) in combination with cisplatin were conducted. In both cases, the dose‐limiting toxicities were leukopenia and/or diarrhea. During these trials the pharmacokinetics of CPT‐11 and its active metabolite, 7‐ethyl‐10‐hydroxycamptothecin (SN‐38), were investigated...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Kudoh, Shinzoh, Fukuoka, Masahiro, Masuda, Noriyuki, Yoshikawa, Atsuko, Kusunoki, Yoko, Matsui, Kaoru, Negoro, Shun‐ichi, Takifuji, Nobuhide, Nakagawa, Kazuhiko, Hirashima, Tomonori, Yana, Takashi, Takada, Minoru
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 1995
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5920836/
https://ncbi.nlm.nih.gov/pubmed/7775263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1995.tb03071.x
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados