4-Methylumbelliferone inhibits enhanced hyaluronan synthesis and cell migration in pancreatic cancer cells in response to tumor-stromal interactions

Hyaluronic acid (HA) in tumor stroma promotes tumor invasion and progression. 4-Methylumbelliferone (4-MU) is a potent HA synthesis inhibitor. In the present study, the effects of 4-MU on enhanced HA synthesis and cell migration in pancreatic ductal adenocarcinoma (PDAC) cells, in response to co-cul...

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Bibliographic Details
Published in:Oncol Lett
Main Authors: Cheng, Xiao-Bo, Sato, Norihiro, Kohi, Shiro, Koga, Atsuhiro, Hirata, Keiji
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2018
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5920249/
https://ncbi.nlm.nih.gov/pubmed/29725394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2018.8147
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