Skin infection boosts memory B-cells specific for a cryptic vaccine epitope of group A streptococcus and broadens the immune response to enhance vaccine efficacy

Antigenic diversity of the M protein is a major constraint to the development of immunity to group A streptococcus (GAS). We demonstrate that a conserved cryptic epitope that is unrecognized by the host immune system following infection can protect mice following vaccination, and that immunity is st...

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Detalhes bibliográficos
Publicado no:NPJ Vaccines
Main Authors: Pandey, Manisha, Ozberk, Victoria, Langshaw, Emma L., Calcutt, Ainslie, Powell, Jessica, Batzloff, Michael R., Rivera-Hernandez, Tania, Good, Michael F.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5920117/
https://ncbi.nlm.nih.gov/pubmed/29736269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-018-0053-9
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