A PET imaging agent for evaluating PARP-1 expression in ovarian cancer

BACKGROUND. Poly(ADP-ribose) polymerase (PARP) inhibitors are effective in a broad population of patients with ovarian cancer; however, resistance caused by low enzyme expression of the drug target PARP-1 remains to be clinically evaluated in this context. We hypothesize that PARP-1 expression is va...

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Vydáno v:J Clin Invest
Hlavní autoři: Makvandi, Mehran, Pantel, Austin, Schwartz, Lauren, Schubert, Erin, Xu, Kuiying, Hsieh, Chia-Ju, Hou, Catherine, Kim, Hyoung, Weng, Chi-Chang, Winters, Harrison, Doot, Robert, Farwell, Michael D., Pryma, Daniel A., Greenberg, Roger A., Mankoff, David A., Simpkins, Fiona, Mach, Robert H., Lin, Lilie L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Clinical Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919879/
https://ncbi.nlm.nih.gov/pubmed/29509546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI97992
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