Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation

Autoimmune diseases, such as psoriasis and arthritis, show a patchy distribution of inflammation despite systemic dysregulation of adaptive immunity. Thus, additional tissue-derived signals, such as danger-associated molecular patterns (DAMPs), are indispensable for manifestation of local inflammati...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Vogl, Thomas, Stratis, Athanasios, Wixler, Viktor, Völler, Tom, Thurainayagam, Sumita, Jorch, Selina K., Zenker, Stefanie, Dreiling, Alena, Chakraborty, Deblina, Fröhling, Mareike, Paruzel, Peter, Wehmeyer, Corinna, Hermann, Sven, Papantonopoulou, Olympia, Geyer, Christiane, Loser, Karin, Schäfers, Michael, Ludwig, Stephan, Stoll, Monika, Leanderson, Tomas, Schultze, Joachim L., König, Simone, Pap, Thomas, Roth, Johannes
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919817/
https://ncbi.nlm.nih.gov/pubmed/29611822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI89867
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