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An interplay between multiple sirtuins promotes completion of DNA replication in cells with short telomeres

The evolutionarily-conserved sirtuin family of histone deacetylases regulates a multitude of DNA-associated processes. A recent genome-wide screen conducted in the yeast Saccharomyces cerevisiae identified Yku70/80, which regulate nonhomologous end-joining (NHEJ) and telomere structure, as being ess...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Simoneau, Antoine, Ricard, Étienne, Wurtele, Hugo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919697/
https://ncbi.nlm.nih.gov/pubmed/29659581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007356
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