MicroRNA-425 and microRNA-155 cooperatively regulate atrial natriuretic peptide expression and cGMP production

AIMS: Atrial natriuretic peptide (ANP), secreted primarily by atrial cardiomyocytes, decreases blood pressure by raising cyclic 3’,5’-guanosine monophosphate (cGMP) levels and inducing vasorelaxation, natriuresis, and diuresis. Raising the level of ANP has been shown to be an effective treatment for...

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Udgivet i:PLoS One
Main Authors: Vandenwijngaert, Sara, Ledsky, Clara D., Agha, Obiajulu, Wu, Connie, Hu, Dongjian, Bagchi, Aranya, Domian, Ibrahim J., Buys, Emmanuel S., Newton-Cheh, Christopher, Bloch, Donald B.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919659/
https://ncbi.nlm.nih.gov/pubmed/29698509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0196697
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