Isolation and molecular characterization of novel glucarpidases: Enzymes to improve the antibody directed enzyme pro-drug therapy for cancer treatment

Repeated cycles of antibody-directed enzyme pro-drug therapy (ADEPT) and the use of glucarpidase in the detoxification of cytotoxic methotrexate (MTX) are highly desirable during cancer therapy but are hampered by the induced human antibody response to glucarpidase. Novel variants of glucarpidase (f...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS One
Egile Nagusiak: Rashidi, Fatma B., AlQhatani, Alanod D., Bashraheel, Sara S., Shaabani, Shabnam, Groves, Matthew R., Dömling, Alexander, Goda, Sayed K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2018
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919439/
https://ncbi.nlm.nih.gov/pubmed/29698433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0196254
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