Isolation and molecular characterization of novel glucarpidases: Enzymes to improve the antibody directed enzyme pro-drug therapy for cancer treatment

Repeated cycles of antibody-directed enzyme pro-drug therapy (ADEPT) and the use of glucarpidase in the detoxification of cytotoxic methotrexate (MTX) are highly desirable during cancer therapy but are hampered by the induced human antibody response to glucarpidase. Novel variants of glucarpidase (f...

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Detalhes bibliográficos
Publicado no:PLoS One
Principais autores: Rashidi, Fatma B., AlQhatani, Alanod D., Bashraheel, Sara S., Shaabani, Shabnam, Groves, Matthew R., Dömling, Alexander, Goda, Sayed K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919439/
https://ncbi.nlm.nih.gov/pubmed/29698433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0196254
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