Calorie Restriction Governs Intestinal Epithelial Regeneration through Cell-Autonomous Regulation of mTORC1 in Reserve Stem Cells

Aging is a complex process associated with a decline in functionality of adult stem cells affecting tissue homeostasis and regeneration. Calorie restriction (CR) is the only experimental manipulation known to extend lifespan and reduce the incidence of age-related disorders across numerous species....

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Veröffentlicht in:Stem Cell Reports
Hauptverfasser: Yousefi, Maryam, Nakauka-Ddamba, Angela, Berry, Corbett T., Li, Ning, Schoenberger, Jenna, Simeonov, Kamen P., Cedeno, Ryan J., Yu, Zhengquan, Lengner, Christopher J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2018
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Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919411/
https://ncbi.nlm.nih.gov/pubmed/29478893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.01.026
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