TRPA1 is required for TGF-β signaling and its loss blocks inflammatory fibrosis in mouse corneal stroma

We examined whether the loss of transient receptor potential ankyrin 1 (TRPA1), an irritant-sensing ion channel, or TRPA1 antagonist treatment affects the severity inflammation and scarring during tissue wound healing in a mouse cornea injury model. In addition, the effects of the absence of TRPA1 o...

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Vydáno v:Lab Invest
Hlavní autoři: Okada, Yuka, Shirai, Kumi, Reinach, Peter S, Kitano-Izutani, Ai, Miyajima, Masayasu, Flanders, Kathleen C, Jester, James V, Tominaga, Makoto, Saika, Shizuya
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919187/
https://ncbi.nlm.nih.gov/pubmed/25068659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2014.85
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