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DNA Damage and Cell Killing by Camptothecin and Its Derivative in Human Leukemia HL‐60 Cells
Camptothecin (CPT) has heen recognized as a topoisomerase I (Topo I) inhibitor. However, the mechanism of cytotoxicity of this agent remains unknown. In the present study, we analyzed the kinetics of Topo I‐mediated DNA single‐strand breaks and internucleosomal DNA cleavage produced by CPT and its d...
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| Udgivet i: | Jpn J Cancer Res |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Blackwell Publishing Ltd
1993
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5919177/ https://ncbi.nlm.nih.gov/pubmed/8391526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1993.tb00177.x |
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