Oligomeric interfaces as a tool in drug discovery: Specific interference with activity of malate dehydrogenase of Plasmodium falciparum in vitro

Malaria remains a major threat to human health, as strains resistant to current therapeutics are discovered. Efforts in finding new drug targets are hampered by the lack of sufficiently specific tools to provide target validation prior to initiating expensive drug discovery projects. Thus, new appro...

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Udgivet i:PLoS One
Main Authors: Lunev, Sergey, Butzloff, Sabine, Romero, Atilio R., Linzke, Marleen, Batista, Fernando A., Meissner, Kamila A., Müller, Ingrid B., Adawy, Alaa, Wrenger, Carsten, Groves, Matthew R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919072/
https://ncbi.nlm.nih.gov/pubmed/29694407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0195011
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