Adduct Formation at C‐8 of Guanine on in vitro Reaction f the Ultimate Form of 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine with 2′‐Deoxyguanosine and Its Phosphate Esters

We examined the reactivity of the N‐hydroxyamino derivative of a carcinogenic heterocyclic amine, 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP), after its O‐acetylation with four 2′‐deoxyribonucleoside 3′‐monophosphates. (32)P‐Postlabeling analysis demonstrated that the levels of adducts wi...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Nagaoka, Hiroaki, Wakabayashi, Keiji, Kim, Seon‐Bong, Kim, In‐Soo, Tanaka, Yoshino, Ochiai, Masako, Tada, Akihiro, Nukaya, Haruo, Sugimura, Takashi, Nagao, Minako
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 1992
Assuntos:
Rapid Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5918676/
https://ncbi.nlm.nih.gov/pubmed/1452454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1992.tb02716.x
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