OPRM1 Methylation Contributes to Opioid Tolerance in Cancer Patients

Cancer patients in pain require high doses of opioids and quickly become opioid-tolerant. Previous studies have shown that chronic cancer pain as well as high-dose opioid use lead to mu-opioid receptor downregulation. In this study we explore downregulation of the mu-opioid receptor gene (OPRM1), as...

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Udgivet i:J Pain
Main Authors: Viet, Chi T., Dang, Dongmin, Aouizerat, Bradley E., Miaskowski, Christine, Ye, Yi, Viet, Dan T., Ono, Kentaro, Schmidt, Brian L.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5918413/
https://ncbi.nlm.nih.gov/pubmed/28456745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2017.04.001
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