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OPRM1 Methylation Contributes to Opioid Tolerance in Cancer Patients
Cancer patients in pain require high doses of opioids and quickly become opioid-tolerant. Previous studies have shown that chronic cancer pain as well as high-dose opioid use lead to mu-opioid receptor downregulation. In this study we explore downregulation of the mu-opioid receptor gene (OPRM1), as...
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| Опубликовано в: : | J Pain |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5918413/ https://ncbi.nlm.nih.gov/pubmed/28456745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2017.04.001 |
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