TGF-β Signaling Accelerates Senescence of Human Bone-Derived CD271 and SSEA-4 Double-Positive Mesenchymal Stromal Cells

It is generally thought that the proliferative capacity and differentiation potential of somatic stem cells, including mesenchymal stromal/stem cells (MSCs) and hematopoietic stem cells, decline with age. We investigated the effects of aging on human bone-derived MSCs expressing CD271 and SSEA-4 (do...

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Vydáno v:Stem Cell Reports
Hlavní autoři: Kawamura, Hiroshi, Nakatsuka, Ryusuke, Matsuoka, Yoshikazu, Sumide, Keisuke, Fujioka, Tatsuya, Asano, Hiroaki, Iida, Hirokazu, Sonoda, Yoshiaki
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5918367/
https://ncbi.nlm.nih.gov/pubmed/29478902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.01.030
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