Mitochondrial Dysfunctions Contribute to Hypertrophic Cardiomyopathy in Patient iPSC-Derived Cardiomyocytes with MT-RNR2 Mutation

Hypertrophic cardiomyopathy (HCM) is the most common cause of sudden cardiac death in young individuals. A potential role of mtDNA mutations in HCM is known. However, the underlying molecular mechanisms linking mtDNA mutations to HCM remain poorly understood due to lack of cell and animal models. He...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Li, Shishi, Pan, Huaye, Tan, Chao, Sun, Yaping, Song, Yanrui, Zhang, Xuan, Yang, Wei, Wang, Xuexiang, Li, Dan, Dai, Yu, Ma, Qiang, Xu, Chenming, Zhu, Xufen, Kang, Lijun, Fu, Yong, Xu, Xuejun, Shu, Jing, Zhou, Naiming, Han, Feng, Qin, Dajiang, Huang, Wendong, Liu, Zhong, Yan, Qingfeng
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5918198/
https://ncbi.nlm.nih.gov/pubmed/29456182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.01.013
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