The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression

Recently, we identified ELL2 as a susceptibility gene for multiple myeloma (MM). To understand its mechanism of action, we performed expression quantitative trait locus analysis in CD138(+) plasma cells from 1630 MM patients from four populations. We show that the MM risk allele lowers ELL2 expressi...

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Publicado en:Nat Commun
Main Authors: Ali, Mina, Ajore, Ram, Wihlborg, Anna-Karin, Niroula, Abhishek, Swaminathan, Bhairavi, Johnsson, Ellinor, Stephens, Owen W, Morgan, Gareth, Meissner, Tobias, Turesson, Ingemar, Goldschmidt, Hartmut, Mellqvist, Ulf-Henrik, Gullberg, Urban, Hansson, Markus, Hemminki, Kari, Nahi, Hareth, Waage, Anders, Weinhold, Niels, Nilsson, Björn
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5917026/
https://ncbi.nlm.nih.gov/pubmed/29695719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04082-2
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