Non-canonical activation of hedgehog in prostate cancer cells mediated by the interaction of transcriptionally active androgen receptor proteins with Gli3

Hedgehog (Hh) is an oncogenic signaling pathway that regulates the activity of Gli transcription factors. Canonical Hh is a Smoothened- (Smo-) driven process that alters the post-translational processing of Gli2/Gli3 proteins. Though evidence supports a role for Gli action in prostate cancer (PCa) c...

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Publicado en:Oncogene
Main Authors: Li, Na, Truong, Sarah, Nouri, Mannan, Moore, Jackson, Al Nakouzi, Nader, Lubik, Amy Anne, Buttyan, Ralph
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916917/
https://ncbi.nlm.nih.gov/pubmed/29429990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-017-0098-7
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