Polyamine Control of Translation Elongation Regulates Start Site Selection on the Antizyme Inhibitor mRNA via Ribosome Queuing

Translation initiation is typically restricted to AUG codons, and scanning eukaryotic ribosomes inefficiently recognize near-cognate codons. We show that queuing of scanning ribosomes behind a paused elongating ribosome promotes initiation at upstream weak start sites. Ribosomal profiling reveals po...

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Detaylı Bibliyografya
Yayımlandı:Mol Cell
Asıl Yazarlar: Ivanov, Ivaylo P., Shin, Byung-Sik, Loughran, Gary, Tzani, Ioanna, Young-Baird, Sara K., Cao, Chune, Atkins, John F., Dever, Thomas E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916843/
https://ncbi.nlm.nih.gov/pubmed/29677493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.03.015
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