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Polyamine Control of Translation Elongation Regulates Start Site Selection on the Antizyme Inhibitor mRNA via Ribosome Queuing
Translation initiation is typically restricted to AUG codons, and scanning eukaryotic ribosomes inefficiently recognize near-cognate codons. We show that queuing of scanning ribosomes behind a paused elongating ribosome promotes initiation at upstream weak start sites. Ribosomal profiling reveals po...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5916843/ https://ncbi.nlm.nih.gov/pubmed/29677493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.03.015 |
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