mGluR5 Modulation of Behavioral and Epileptic Phenotypes in a Mouse Model of Tuberous Sclerosis Complex

Drugs targeting metabotropic glutamate receptor 5 (mGluR5) have therapeutic potential in autism spectrum disorders (ASD), including tuberous sclerosis complex (TSC). The question whether inhibition or potentiation of mGluR5 could be beneficial depends, among other factors, on the specific indication...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Kelly, Elyza, Schaeffer, Samantha M, Dhamne, Sameer C, Lipton, Jonathan O, Lindemann, Lothar, Honer, Michael, Jaeschke, Georg, Super, Chloe E, Lammers, Stephen HT, Modi, Meera E, Silverman, Jill L, Dreier, John R, Kwiatkowski, David J, Rotenberg, Alexander, Sahin, Mustafa
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2018
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916364/
https://ncbi.nlm.nih.gov/pubmed/29206810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2017.295
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