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Concomitant BCORL1 and BRAF Mutations in Vemurafenib-Resistant Melanoma Cells()
BRAF is the most frequently mutated gene in melanoma. Constitutive activation of mutant BRAF(V600E) leads to aberrant Ras-independent MAPK signaling and cell transformation. Inhibition of mutant BRAF is a current frontline therapy for such cases, with improved survival compared with chemotherapy. Un...
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| Publicado no: | Neoplasia |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Neoplasia Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5915992/ https://ncbi.nlm.nih.gov/pubmed/29605720 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2018.02.009 |
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