Concomitant BCORL1 and BRAF Mutations in Vemurafenib-Resistant Melanoma Cells()

BRAF is the most frequently mutated gene in melanoma. Constitutive activation of mutant BRAF(V600E) leads to aberrant Ras-independent MAPK signaling and cell transformation. Inhibition of mutant BRAF is a current frontline therapy for such cases, with improved survival compared with chemotherapy. Un...

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Vydáno v:Neoplasia
Hlavní autoři: Mologni, Luca, Costanza, Mariantonia, Sharma, Geeta Geeta, Viltadi, Michela, Massimino, Luca, Citterio, Stefania, Purgante, Stefania, Raman, Hima, Pirola, Alessandra, Zucchetti, Massimo, Piazza, Rocco, Gambacorti-Passerini, Carlo
Médium: Artigo
Jazyk:Inglês
Vydáno: Neoplasia Press 2018
Témata:
Original article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915992/
https://ncbi.nlm.nih.gov/pubmed/29605720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2018.02.009
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