Matrix metalloproteinase-9 might affect adaptive immunity in non-ST segment elevation acute coronary syndromes by increasing CD31 cleavage on CD4+ T-cells

AIMS: In patients with acute coronary syndrome (ACS), the higher activity of effector T-cells suggests that mechanisms involving adaptive immunity dysregulation might play a role in coronary instability. The shedding of the functional CD31 domain 1–5 leads to uncontrolled lymphocyte activation. In e...

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Publicado en:Eur Heart J
Autores principales: Angelini, Giulia, Flego, Davide, Vinci, Ramona, Pedicino, Daniela, Trotta, Francesco, Ruggio, Aureliano, Piemontese, Giuseppe P, Galante, Domenico, Ponzo, Myriana, Biasucci, Luigi M, Liuzzo, Giovanna, Crea, Filippo
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
Materias:
Basic Science
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915953/
https://ncbi.nlm.nih.gov/pubmed/29211854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehx684
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