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Structural basis for the activation of acid ceramidase
Acid ceramidase (aCDase, ASAH1) hydrolyzes lysosomal membrane ceramide into sphingosine, the backbone of all sphingolipids, to regulate many cellular processes. Abnormal function of aCDase leads to Farber disease, spinal muscular atrophy with progressive myoclonic epilepsy, and is associated with Al...
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| Izdano u: | Nat Commun |
|---|---|
| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5915598/ https://ncbi.nlm.nih.gov/pubmed/29692406 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03844-2 |
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