Galectin-3 deficiency drives lupus-like disease by promoting spontaneous germinal centers formation via IFN-γ

Germinal centers (GC) are important sites for high-affinity and long-lived antibody induction. Tight regulation of GC responses is critical for maintaining self-tolerance. Here, we show that Galectin-3 (Gal-3) is involved in GC development. Compared with WT mice, Gal-3 KO mice have more GC B cells a...

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Vydáno v:Nat Commun
Hlavní autoři: Beccaria, Cristian Gabriel, Amezcua Vesely, María Carolina, Fiocca Vernengo, Facundo, Gehrau, Ricardo Carlos, Ramello, María Cecilia, Tosello Boari, Jimena, Gorosito Serrán, Melisa, Mucci, Juan, Piaggio, Eliane, Campetella, Oscar, Acosta Rodríguez, Eva Virginia, Montes, Carolina Lucía, Gruppi, Adriana
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915532/
https://ncbi.nlm.nih.gov/pubmed/29691398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04063-5
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