The Neutral Sphingomyelinase 2 Is Required to Polarize and Sustain T Cell Receptor Signaling

By promoting ceramide release at the cytosolic membrane leaflet, the neutral sphingomyelinase 2 (NSM) is capable of organizing receptor and signalosome segregation. Its role in T cell receptor (TCR) signaling remained so far unknown. We now show that TCR-driven NSM activation is dispensable for TCR...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Börtlein, Charlene, Draeger, Annette, Schoenauer, Roman, Kuhlemann, Alexander, Sauer, Markus, Schneider-Schaulies, Sibylle, Avota, Elita
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915489/
https://ncbi.nlm.nih.gov/pubmed/29720981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00815
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