Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

In the adult brain, the neural stem cell (NSC) pool comprises quiescent and activated populations with distinct roles. Transcriptomic analysis revealed that quiescent and activated NSCs exhibited differences in their protein homeostasis network. Whereas activated NSCs had active proteasomes, quiesce...

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Bibliografske podrobnosti
izdano v:Science
Main Authors: Leeman, Dena S., Hebestreit, Katja, Ruetz, Tyson, Webb, Ashley E., McKay, Andrew, Pollina, Elizabeth A., Dulken, Ben W., Zhao, Xiaoai, Yeo, Robin W., Ho, Theodore T., Mahmoudi, Salah, Devarajan, Keerthana, Passegué, Emmanuelle, Rando, Thomas A., Frydman, Judith, Brunet, Anne
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915358/
https://ncbi.nlm.nih.gov/pubmed/29590078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aag3048
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