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Improvement of kynurenine aminotransferase-II inhibitors guided by mimicking sulfate esters
The mammalian kynurenine aminotransferase (KAT) enzymes are a family of related isoforms that are pyridoxal 5’-phosphate-dependent, responsible for the irreversible transamination of kynurenine to kynurenic acid. Kynurenic acid is implicated in human diseases such as schizophrenia where it is found...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5915280/ https://ncbi.nlm.nih.gov/pubmed/29689093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0196404 |
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