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Inhibition of human kynurenine aminotransferase isozymes by estrogen and its derivatives
The kynurenine aminotransferase (KAT) enzymes are pyridoxal 5′-phosphate-dependent homodimers that catalyse the irreversible transamination of kynurenine into kynurenic acid (KYNA) in the tryptophan metabolic pathway. Kynurenic acid is implicated in cognitive diseases such as schizophrenia, and seve...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5730616/ https://ncbi.nlm.nih.gov/pubmed/29242525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17979-7 |
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