PIK3CA mutation, reduced AKT serine 473 phosphorylation, and increased ERα serine 167 phosphorylation are positive prognostic indicators in postmenopausal estrogen receptor-positive early breast cancer

Although endocrine therapy is the most important treatment option in estrogen receptor (ER)-positive breast cancer, new strategies, such as molecular targeted agents together with endocrine therapy are required to improve survival. PIK3CA is the most frequent mutated gene in ER-positive early breast...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Ishida, Naoko, Baba, Motoi, Hatanaka, Yutaka, Hagio, Kanako, Okada, Hiromi, Hatanaka, Kanako C., Togashi, Kenichi, Matsuno, Yoshihiro, Yamashita, Hiroko
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915150/
https://ncbi.nlm.nih.gov/pubmed/29707142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24845
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