Connective tissue growth factor-specific monoclonal antibody inhibits growth of malignant mesothelioma in an orthotopic mouse model

Malignant mesothelioma is an aggressive neoplasm with no particularly effective treatments. We previously reported that overexpression of connective tissue growth factor (CTGF/CCN2) promotes mesothelioma growth, thus suggesting it as a novel molecular target. A human monoclonal antibody that antagon...

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Vydáno v:Oncotarget
Hlavní autoři: Ohara, Yuuki, Chew, Shan Hwu, Misawa, Nobuaki, Wang, Shenqi, Somiya, Daiki, Nakamura, Kae, Kajiyama, Hiroaki, Kikkawa, Fumitaka, Tsuyuki, Yuta, Jiang, Li, Yamashita, Kyoko, Sekido, Yoshitaka, Lipson, Kenneth E., Toyokuni, Shinya
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915087/
https://ncbi.nlm.nih.gov/pubmed/29719620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24892
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