Connective tissue growth factor-specific monoclonal antibody inhibits growth of malignant mesothelioma in an orthotopic mouse model

Malignant mesothelioma is an aggressive neoplasm with no particularly effective treatments. We previously reported that overexpression of connective tissue growth factor (CTGF/CCN2) promotes mesothelioma growth, thus suggesting it as a novel molecular target. A human monoclonal antibody that antagon...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncotarget
Prif Awduron: Ohara, Yuuki, Chew, Shan Hwu, Misawa, Nobuaki, Wang, Shenqi, Somiya, Daiki, Nakamura, Kae, Kajiyama, Hiroaki, Kikkawa, Fumitaka, Tsuyuki, Yuta, Jiang, Li, Yamashita, Kyoko, Sekido, Yoshitaka, Lipson, Kenneth E., Toyokuni, Shinya
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2018
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915087/
https://ncbi.nlm.nih.gov/pubmed/29719620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24892
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