Endonuclease G promotes mitochondrial genome cleavage and replication

Endonuclease G (EndoG) is a nuclear-encoded endonuclease, mostly localised in mitochondria. In the nucleus EndoG participates in site-specific cleavage during replication stress and genome-wide DNA degradation during apoptosis. However, the impact of EndoG on mitochondrial DNA (mtDNA) metabolism is...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Wiehe, Rahel Stefanie, Gole, Boris, Chatre, Laurent, Walther, Paul, Calzia, Enrico, Ricchetti, Miria, Wiesmüller, Lisa
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915074/
https://ncbi.nlm.nih.gov/pubmed/29719607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24822
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