Protocol for a phase III, non-inferiority, randomised comparison of a new fibrinogen concentrate versus cryoprecipitate for treating acquired hypofibrinogenaemia in bleeding cardiac surgical patients: the FIBRES trial

INTRODUCTION: Coagulopathic bleeding is a serious complication of cardiac surgery to which an important contributor is acquired hypofibrinogenaemia (plasma fibrinogen <1.5–2.0 g/L). The standard intervention for acquired hypofibrinogenaemia is cryoprecipitate, but purified fibrinogen concentrates...

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Publicat a:BMJ Open
Autors principals: Karkouti, Keyvan, Callum, Jeannie, Rao, Vivek, Heddle, Nancy, Farkouh, Michael E, Crowther, Mark A, Scales, Damon C
Format: Artigo
Idioma:Inglês
Publicat: BMJ Publishing Group 2018
Matèries:
Haematology (Incl Blood Transfusion)
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5914770/
https://ncbi.nlm.nih.gov/pubmed/29678987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2017-020741
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