Short Proline-Rich Lipopeptide Potentiates Minocycline and Rifampin against Multidrug- and Extensively Drug-Resistant Pseudomonas aeruginosa

A series of 16 short proline-rich lipopeptides (SPRLPs) were constructed to mimic longer naturally existing proline-rich antimicrobial peptides. Antibacterial assessment revealed that lipopeptides containing hexadecanoic acid (C(16)) possess optimal antibacterial activity relative to others with sho...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Domalaon, Ronald, Sanchak, Yaroslav, Koskei, Linet Cherono, Lyu, Yinfeng, Zhanel, George G., Arthur, Gilbert, Schweizer, Frank
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5914005/
https://ncbi.nlm.nih.gov/pubmed/29437631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02374-17
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