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Identification of the In Vivo Pharmacokinetics and Pharmacodynamic Driver of Iclaprim

The neutropenic murine thigh infection model was used to define the pharmacokinetic/pharmacodynamic index linked to efficacy of iclaprim against Staphylococcus aureus ATCC 29213 and Staphylococcus pneumoniae ATCC 10813. The 24-h area under the curve (AUC)/MIC index was most closely linked to efficac...

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書目詳細資料
發表在:Antimicrob Agents Chemother
Main Authors: Park, Jee Hyun, Craig, William, Marchillo, Karen, Huang, David B., Andes, David R.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5913961/
https://ncbi.nlm.nih.gov/pubmed/29378717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02550-17
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