Overexpression of BLM promotes DNA damage and increased sensitivity to platinum salts in triple-negative breast and serous ovarian cancers

BACKGROUND: Platinum-based therapy is an effective treatment for a subset of triple-negative breast cancer and ovarian cancer patients. In order to increase response rate and decrease unnecessary use, robust biomarkers that predict response to therapy are needed. PATIENTS AND METHODS: We performed a...

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Vydáno v:Ann Oncol
Hlavní autoři: Birkbak, N J, Li, Y, Pathania, S, Greene-Colozzi, A, Dreze, M, Bowman-Colin, C, Sztupinszki, Z, Krzystanek, M, Diossy, M, Tung, N, Ryan, P D, Garber, J E, Silver, D P, Iglehart, J D, Wang, Z C, Szuts, D, Szallasi, Z, Richardson, A L
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5913643/
https://ncbi.nlm.nih.gov/pubmed/29452344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdy049
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