Telomeric allelic imbalance indicates defective DNA repair and sensitivity to DNA damaging agents

DNA repair competency is one determinant of sensitivity to certain chemotherapy drugs, such as cisplatin. Cancer cells with intact DNA repair can avoid the accumulation of genome damage during growth and also can repair platinum-induced DNA damage. We sought genomic signatures indicative of defectiv...

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Hlavní autoři: Birkbak, Nicolai J., Wang, Zhigang C., Kim, Ji-Young, Eklund, Aron C., Li, Qiyuan, Tian, Ruiyang, Bowman-Colin, Christian, Li, Yang, Greene-Colozzi, April, Iglehart, J. Dirk, Tung, Nadine, Ryan, Paula D., Garber, Judy E., Silver, Daniel P., Szallasi, Zoltan, Richardson, Andrea L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3806629/
https://ncbi.nlm.nih.gov/pubmed/22576213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0206
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