Facilitation of ischaemia‐induced ventricular fibrillation by catecholamines is mediated by β(1) and β(2) agonism in the rat heart in vitro

BACKGROUND AND PURPOSE: Antiarrhythmic β‐blockers are used in patients at risk of myocardial ischaemia, but the survival benefit and mechanisms are unclear. We hypothesized that β‐blockers do not prevent ventricular fibrillation (VF) but instead inhibit the ability of catecholamines to facilitate is...

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Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Wilder, Catherine D E, Pavlaki, Nikoleta, Dursun, Tutku, Gyimah, Paul, Caldwell‐Dunn, Ellice, Ranieri, Antonella, Lewis, Hannah R, Curtis, Michael J
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5913407/
https://ncbi.nlm.nih.gov/pubmed/29473948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14176
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