A novel in vitro metric predicts in vivo efficacy of inhaled silver-based antimicrobials in a murine Pseudomonas aeruginosa pneumonia model

To address the escalating problem of antimicrobial resistance and the dwindling antimicrobial pipeline, we have developed a library of novel aerosolizable silver-based antimicrobials, particularly for the treatment of pulmonary infections. To rapidly screen this library and identify promising candid...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Shah, Parth N., Shah, Kush N., Smolen, Justin A., Tagaev, Jasur A., Torrealba, Jose, Zhou, Lan, Zhang, Shiyi, Zhang, Fuwu, Wagers, Patrick O., Panzner, Matthew J., Youngs, Wiley J., Wooley, Karen L., Cannon, Carolyn L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5913254/
https://ncbi.nlm.nih.gov/pubmed/29686296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24200-w
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