Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in β(2)AR-cAMP Responsiveness in Murine Hearts

Cardiomyocytes from the apex but not the base of the heart increase their contractility in response to β(2)-adrenoceptor (β(2)AR) stimulation, which may underlie the development of Takotsubo cardiomyopathy. However, both cell types produce comparable cytosolic amounts of the second messenger cAMP. W...

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Publicat a:Cell Rep
Autors principals: Wright, Peter T., Bhogal, Navneet K., Diakonov, Ivan, Pannell, Laura M.K., Perera, Ruwan K., Bork, Nadja I., Schobesberger, Sophie, Lucarelli, Carla, Faggian, Giuseppe, Alvarez-Laviada, Anita, Zaccolo, Manuela, Kamp, Timothy J., Balijepalli, Ravi C., Lyon, Alexander R., Harding, Sian E., Nikolaev, Viacheslav O., Gorelik, Julia
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912947/
https://ncbi.nlm.nih.gov/pubmed/29642004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.03.053
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