Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol

Controlled distribution of lipids across various cell membranes is crucial for cell homeostasis and regulation. We developed an imaging method that allows simultaneous in situ quantification of cholesterol in two leaflets of the plasma membrane (PM) using tunable orthogonal cholesterol sensors. Our...

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Publié dans:Nat Chem Biol
Auteurs principaux: Liu, Shu-Lin, Sheng, Ren, Jung, Jae Hun, Wang, Li, Stec, Ewa, O’Connor, Matthew J, Song, Seohyoen, Bikkavilli, Rama Kamesh, Winn, Robert A, Lee, Daesung, Baek, Kwanghee, Ueda, Kazumitsu, Levitan, Irena, Kim, Kwang-Pyo, Cho, Wonhwa
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912897/
https://ncbi.nlm.nih.gov/pubmed/28024150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2268
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