Two zinc-binding domains in the transporter AdcA from Streptococcus pyogenes facilitate high-affinity binding and fast transport of zinc

Zinc is an essential metal in bacteria. One important bacterial zinc transporter is AdcA, and most bacteria possess AdcA homologs that are single-domain small proteins due to better efficiency of protein biogenesis. However, a double-domain AdcA with two zinc-binding sites is significantly overrepre...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Cao, Kun, Li, Nan, Wang, Hongcui, Cao, Xin, He, Jiaojiao, Zhang, Bing, He, Qing-Yu, Zhang, Gong, Sun, Xuesong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912482/
https://ncbi.nlm.nih.gov/pubmed/29491141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.818997
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